Pharmacological interventions for alcohol relapse prevention

Received: December 09, 2014
Accepted: February 08, 2015
Ref: Chithiramohan A, George S. Pharmacological interventions for alcohol relapse prevention. Internet J Med Update. 2015 Jul;10(2):41-45. doi: 10.4314/ijmu.v10i2.7
CrossRef Link: http://dx.doi.org/10.4314/ijmu.v10i2.7

Anita Chithiramohan*, Sanju George**

*University College London Medical School, Gower Street, London, UK
**Solihull Integrated Addiction Services (SIAS), Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, UK

(Corresponding Author: Dr. Sanju George, Consultant in addiction psychiatry, Solihull Integrated Addiction Services (SIAS), Birmingham and Solihull Mental Health NHS Foundation Trust, Birmingham, B37 7UR, UK; Email: sanju.george@talk21.com)

ABSTRACT

Alcohol dependence is a chronic, debilitating disorder that is an important public health problem worldwide. Combined psychological and pharmacological treatment packages produce best outcomes in its management. In this paper we discuss the three NICE – approved relapse prevention medications used in treatment of alcohol dependence: acamprosate, naltrexone and disulfiram. We review the pharmacological profile, mode of action, pharmacokinetics, and safety and tolerability of each of these pharmacological interventions. We discuss how each intervention can be used in clinical practice and review the efficacy of each drug. No one drug is clearly superior to the other, and clinical factors and patient choice should inform the choice of drug.

KEY WORDS: Alcohol; Dependence; Pharmacological treatment

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