Interaction between anti-hypertensive and non-steroidal anti inflammatory drugs: implications in management of osteoarthritis and opinion on a compromise therapy

Received: May 19, 2009
Accepted: July 26, 2009
Ref: Hamzat TK, Ajala AO. Interaction between anti-hypertensive and non-steroidal anti inflammatory drugs: implications in management of osteoarthritis and opinion on a compromise therapy. Internet J Med Update 2010 Jan;5(1):42-47.

INTERACTION BETWEEN ANTI-HYPERTENSIVE AND NON-STEROIDAL ANTI INFLAMMATORY DRUGS: IMPLICATIONS IN MANAGEMENT OF OSTEOARTHRITIS AND OPINION ON A COMPROMISE THERAPY

Dr. Talhatu K. Hamzat^† PhD and Mr. Adeolu O. Ajala^‡ MSc

^†Senior Lecturer and Consultant Clinical Physiotherapist, ^‡Physiotherapist, Department of Physiotherapy, College of Medicine, University College Hospital, University of Ibadan, Nigeria

(Corresponding Author: Dr. Talhatu K. Hamzat, Department of Physiotherapy, College of Medicine, University College Hospital, University of Ibadan, PMB 5017 GPO Dugbe, Ibadan, Nigeria, Email: talkzat@yahoo.com)

ABSTRACT

The premise for this article is that a significant proportion of patients presenting in the clinic with osteoarthritis have hypertension as co-morbidity. A common drug of choice in managing symptoms of osteoarthritis including those affecting the knee joint is the Non-Steroidal Anti-Inflammatory Drugs (NSAIDS) groups. It has been reported however that NSAIDs diminish the effects of anti-hypertensive drugs and may lead to an ineffective hypertension therapy. In order to avoid complications in the health of the patient with concomitant hypertension and osteoarthritis and who are on both antihypertensive and NSAIDs, it becomes imperative to consider using non-pharmacologic approaches such as physiotherapy in managing the symptoms of osteoarthritis in this group of patients and thereby maximizing the effects of their antihypertensive therapy. This is more so that information exists on efficacy of physiotherapy in form of therapeutic exercises and electrotherapeutic modalities in management of clinical features of osteoarthritis.

KEY WORDS: NSAIDS; Anti-hypertensive drugs; Interaction; Osteoarthritis; Management

Note: Some rights reserved. The materials of this electronic journal are copyrighted © by Dr. Arun Kumar Agnihotri “A K S Publication”. No part of this publication may be reproduced by any means without the written permission of the copyright holder. The readers of this journal are free to download, copy, print, distribute and display the work provided; they must give the original author credit, not use this work for commercial purpose, and not alter, transform, or build upon this work.