ABSTRACT

Although blood transfusion is a life-saving maneuver, it is associated with certain risks. In general, transfusion-related adverse events are categorized as infectious and noninfectious. Transfusion-transmissible infectious agents such as human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV) and syphilis are among the greatest threats to blood safety for the recipient. To assess the magnitude and dynamics of disease transmission and for its prevention and control, the study of its seroprevalence is important. Our institute, catering to the needs of a large population in the foothills of the Himalayas, represents an important center for serological surveys. This study aimed to determine the seroprevalence of HIV, HBV, HCV and syphilis infections among blood donors in a tertiary care center of this region. A retrospective analysis of medical records of blood donors who met the standard criteria for donor fitness were screened for HIV, HBS, HCV, Syphilis and Malaria, from January 2007 to December 2011 (5 years). Out of 7884 units collected, 83 (1.05%) units had seropositivity for HBsAg/anti-HCV Ab/anti-HIV Ab/anti-Treponemal Ab, 2 units each revealed dual infections with HIV-HBV and HIV-HCV. Seropositivity rates of HBsAg, anti-HCV Ab, anti-HIV Ab and anti-treponemal Ab were 0.63%, 0.20%, 0.19% and 0.02%, respectively. Even with the implementation of effective preventive strategies, there is significant risk of transmission of infectious agents in India. Efforts to ensure an adequate and safe blood supply should include proper screening and striving for optimal use of blood and its products.

KEY WORDS: Seroprevalence; HIV; Hepatitis B; Hepatitis C; Syphilis; Uttarakhand